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A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes

✍ Scribed by France Mentre; Jean-Louis Steimer; Jean-Pierre Sommadossi; Robert B. Diasio; Jean-Paul Cano

Book ID
115777910
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
451 KB
Volume
33
Category
Article
ISSN
0006-2952

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The use of isolated rat hepatocytes in studies of drug metabolism has become well documented in the past few years. However, in part because of modelling difficulties due to the simultaneously occurring substrate transferring processes, its predictability of in vivo situations has not been emphasize