A mathematical model of chemoreflex responses to hypercapnic stimuli

✍ Scribed by William S. Yamamoto; Polly S. Yamamoto

• Publisher: Elsevier Science
• Year: 1979
• Tongue: English
• Weight: 734 KB
• Volume: 12
• Category: Article
• ISSN: 0010-4809
• DOI: 10.1016/0010-4809(79)90007-7

✦ Synopsis

A mathematical model of the carotid body chemoreceptor reflex was constructed using firstorder recursive digital filter expressions for the chemoreceptor excitatory state, neural impulses from non-negative excitatory states, and a switched recursive filter system for the central pathways. The switching between central filters was employed to represent the apparent alteration in effect of afferent impulses arriving at different phases of the central respiratory cycle. The equations were programmed for computation. When connected to a subsidiary system representing the chest and a central respiratory drive, the principal features of the CO, responses of the carotid body, the afferent carotid body nerve, and the central pathways as reported from experiments on the cat could be simulated with a single set of parameters. The model is suitable for integration into larger models for investigation of the control of ventilation.