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A Mathematical Model for the Germinal Center Morphology and Affinity Maturation

โœ Scribed by MICHAEL MEYER-HERMANN

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
770 KB
Volume
216
Category
Article
ISSN
0022-5193

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โœฆ Synopsis

During germinal center reactions, the appearance of two specific zones are observed: the dark and the light zone. Up to now, the origin and function of these zones are poorly understood. In the framework of a stochastic and discrete model, several possible pathways of zone development during germinal center reactions are investigated. The importance of the zones in the germinal center for affinity maturation, i.e. the process of antibody optimization is discussed.

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