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A mathematical model for the control mechanism of free fatty acid-glucose metabolism in normal humans

✍ Scribed by R. Srinivasan; Arnold H. Kadish; R. Sridhar

Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
980 KB
Volume
3
Category
Article
ISSN
0010-4809

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✦ Synopsis

This paper presents a mathematical model for the control mechanism of free fatty acid-glucose metabolism under resting conditions in normal humans. The objective is to explain in a consistent manner clinical laboratory observations such as glucose, insulin and free fatty acid responses to intravenous glucose, insulin, etc. At present attention is focused on only short-term effects. The model is an extension of the one for glucose homeostasis proposed by Charette, Kadish, and Sridhar (4,5). It is based upon a systems approach and agrees with current theories of glucose and free fatty acid metabolism. Description is in terms of ordinary differential equations and validation is based on clinical laboratory data.

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