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A Mathematical Analysis Using Fractals for Binding Interactions of Nuclear Estrogen Receptors Occurring on Biosensor Surfaces

✍ Scribed by Anand Ramakrishnan; Ajit Sadana

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
170 KB
Volume
303
Category
Article
ISSN
0003-2697

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✦ Synopsis

A mathematical approach using fractal concepts is presented for modeling the binding and dissociation interactions between analytes and nuclear estrogen receptors (ER) occurring on surface plasmon resonance biosensor chip surfaces. A kinetic knowledge of the binding interactions mediated by ER would help in better understanding the carcinogenicity of these steroidogenic compounds and assist in modulating these reactions. The fractal approach is applied to analyte-ER interaction data obtained from literature. Numerical values obtained for the binding and dissociation rate coefficients are linked to the degree of roughness or heterogeneity (fractal dimension, D f ) present on the biosensor surface. For example, a single-fractal analysis is used to describe the binding and dissociation phases for the binding of estradiol and ER␣ in solution to clone 31 protein immobilized on a biosensor chip (C-S.

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