## Abstract A new method of general applicability for determining the percentage deuterium labeling in organic compounds is described. It uses the heights of โmetastable peaksโ in the mass spectrum to determine the relative amounts of deuterated and undeuterated species. The method is illustrated b
A mass spectrometric method for the determination of stable isotope labeled phenytoin suitable for pulse dosing studies
โ Scribed by A. van Langenhove; C. E. Costello; J. E. Biller; K. Biemann; T. R. Browne
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 552 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1076-5174
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A liquid chromatographic-electrospray ionizationtandem mass spectrometric method has been developed and validated for determination of the antiabuse medication, buprenorphine, its primary metabolite, norbuprenorphine, and a proposed coformulant, naloxone. The method uses deuterated internal standard