𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A malaria vaccine strategy based on the induction of cellular immunity

✍ Scribed by Michael F Good

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
475 KB
Volume
13
Category
Article
ISSN
0167-5699

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The C terminus of the circumsporozoite protein (CSP) is anchored to the parasite cell membrane by a glycosylphosphatidylinositol (GPI) glycolipid. This GPI signal sequence functions poorly in heterologous eukaryotic cells, causing CSP retention within internal cell organelles during genetic immuniza