A macrolactonization-based strategy to obtain microtuble-stabilizing agent (−)-laulimalide

✍ Scribed by Arun K Ghosh; Yong Wang

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 89 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00436-1

✦ Synopsis

An alternative synthesis of anti-tumor macrolide (-)-laulimalide is described. The synthesis was achieved utilizing Yamaguchi macrolactonization as the key step. The sensitive C-C -olefin functionality has been installed by a macrolactonization of hydroxy alkynic acid and subsequent hydrogenation over Lindlar's catalyst.