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A loss of function mutation in WISP3 derived from microsatellite unstable gastric carcinoma

✍ Scribed by Shinji Tanaka; Keishi Sugimachi; Shin-Ichiro Maehara; Mitsuo Shimada; Yoshihiko Maehara


Book ID
119241052
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
103 KB
Volume
125
Category
Article
ISSN
0016-5085

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## Abstract Accumulation of genetic alterations in oncogenes and tumor suppressor genes causes the transformation of a normal cell into a malignant cell. Recently, Fearon and Vogelstein (Cell 61:759‐767, 1990) reported on a model for the genetic pathway in development of colorectal neoplasia. To in