A patient with Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) was diagnosed with cutaneous sarcoidosis after treatment with interferon-alpha (IFN-␣). Following IFN-␣ dose reduction, the skin lesions disappeared. Few cases of sarcoidosis associated with IFN treatment have been reporte
A long-term suppression by α-interferon of Philadelphia chromosome in children with chronic myelogenous leukemia
✍ Scribed by YOSHIHARU KIKAWA; YASUSHI FUJI; TOMOKO TAKANO; YOUSUKE SHIGEMATSU; MASAKATSU SUDO; MASANORI OKAMOTO; SHUKI MIZUTANI
- Book ID
- 118711892
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 387 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1328-8067
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In a pilot study, 32 patients with Philadelphia chromosome-positive chronic myelogenous leukemia were treated with intensive chemotherapy induction followed by interferon-alpha (IFN-A) maintenance. Intensive chemotherapy consisted of three cycles of daunorubicin 120 mg/mz on day 1, cytarabine 80 mg/
Background. Five to 10% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia chromosome (Ph), but one-third of them have rearrangements of the breakpoint cluster region (BCR-positive). Methods. The authors analyzed the characteristics, treatment response, and prognosis o