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A Long term observation on the change of parenchymal tissue and of hepatic vasculature after the portocaval anastomosis

✍ Scribed by Takahashi, T. ;Watanabe, J. ;Horiguchi, M. ;Yoshida, M. ;Yoshimura, S. ;Kiyokawa, A. ;Abe, A. ;Ozawa, Y. ;Noguchi, S. ;Takahashi, A. ;Sugiura, M. ;Ogawa, K.


Publisher
Springer-Verlag
Year
1966
Tongue
English
Weight
66 KB
Volume
1
Category
Article
ISSN
0435-1339

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## Abstract Dichoroacetate (DCA) and trichloroacetate (TCA) were found to be hepatotoxic and hepatocarcinogenic in rodents. To investigate the role of oxidative stress in the long‐term hepatotoxicity of the compounds, groups of mice were administered 7.7, 77, 154 and 410 mg kg^βˆ’1^ per day, of eithe