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A liquid chromatography-mass spectrometry method for nicotine and cotinine; utility in screening tobacco exposure in patients taking amiodarone

✍ Scribed by Raniah Q. Gabr; Marwa E. Elsherbiny; Vishwa Somayaji; P. Timothy Pollak; Dion R. Brocks


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
179 KB
Volume
25
Category
Article
ISSN
0269-3879

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✍ David L. Heavner; Joel D. Richardson; Walter T. Morgan; Michael W. Ogden 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB 👁 1 views

An SPE-LC-MS/MS method was developed, validated and applied to the determination of nicotine and five major metabolites in human urine: cotinine, trans-3'-hydroxycotinine, nicotine-N-glucuronide, cotinine-N-glucuronide and trans-3'-hydroxycotinine-O-glucuronide. A 500 microL urine sample was pH-adju