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A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids

✍ Scribed by Muhammad Faheem Asim; Gerhard Wolber; Mariana Spetea; Helmut Schmidhammer


Publisher
BioMed Central
Year
2010
Tongue
English
Weight
96 KB
Volume
10
Category
Article
ISSN
1471-2210

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We have previously proposed a model for the 6-opioid receptor binding conformation of the high afinity tetrapeptide Tyr-c[D-Cys-Phe-D-Pen] OH (JOM-13) based on experimental and theoretical conformational analysis of lhis peptide and a correlation of conformational preferences of further conformation