Correlating disease-related mutations to
โ
Rita Casadio; Marco Vassura; Shalinee Tiwari; Piero Fariselli; Pier Luigi Martel
๐
Article
๐
2011
๐
John Wiley and Sons
๐
English
โ 613 KB
Single residue mutations in proteins are known to affect protein stability and function. As a consequence, they can be disease associated. Available computational methods starting from protein sequence/structure can predict whether a mutated residue is or not disease associated and whether it is pro