Overexpression of the MDRL gene in blast
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Kees Nooter; Pieter Sonneveld; Robert Oostrum; Hans Herweijer; Ton Hagenbeek; Di
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Article
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1990
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John Wiley and Sons
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French
⚖ 693 KB
## Abstract Typical multi‐drug resistance (MDR) in human and animal cell lines is caused by overactivity of a unidirectional drug efflux pump. This pump is composed of a 170‐kDa transmembrane glycoprotein (P‐glycoprotein) that is encoded by the so‐called __mdrl__ gene. The functionally relevant cha