A lamellar liquid crystal with fosinopril sodium

✍ Scribed by Stig E. Friberg; Teanoosh Moaddel; Kenneth R. Morris; Robert Abramowitz; Kent L. Amsberry

• Book ID: 102413330
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 318 KB
• Volume: 83
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600830517

✦ Synopsis

The location and conformation of fosinopril sodium (FS) in a lamellar liquid crystal of water, sodium dodecyl sulfate, and decanol was studied by low-angle X-ray diffraction. The result showed the FS molecule to be located within the amphiphilic part of the liquid crystalline structure with the polar parts anchored at the water/polar part interface. An area per molecule in the range of 95-100 A2 showed not only the polar groups but also the benzene ring to be located at this interface.