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A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells

✍ Scribed by Carole L. Yauk; John D. Gingerich; Lynda Soper; Avril MacMahon; Warren G. Foster; George R. Douglas

Book ID
113808678
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
167 KB
Volume
578
Category
Article
ISSN
0027-5107

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✍ Vasily N. Dobrovolsky; Daniel A. Casciano; Robert H. Heflich πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 663 KB

A tk+/mouse embryonic stem (ES) cell line, designated 1G2, has been created in which one allele of the thymidine kinase (tk) gene was inactivated by targeted homologous recombination. This line is an analog of the mouse lymphoma tk+/-L5 178Y cell line, which is used widely to assess the mutagenicity