## Abstract ## Background Granulocyteβcolonyβstimulating factor (GMβCSF) is a pleiotropic factor for hematopoiesis that stimulates myeloblasts, monoblasts and mobilization of bone marrow stem cells. Therefore, the GMβCSF gene is a potential candidate for vessel formation and tissue remodeling in t
β¦ LIBER β¦
A Kunjin replicon vector encoding granulocyte macrophage colony-stimulating factor for intra-tumoral gene therapy
β Scribed by Hoang-Le, D; Smeenk, L; Anraku, I; Pijlman, G P; Wang, X J; de Vrij, J; Liu, W J; Le, T T; Schroder, W A; Khromykh, A A
- Book ID
- 109855109
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 226 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0969-7128
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## Background: This phase i trial was developed to determine the safety, biologic activity, and effects on hematopoietic recovery of pixy321 following ifosfamide, carboplatin, and etoposide chemotherapy for children with recurrent or refractory solid tumors. ## Methods: Children (age < 22 years a