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A Kulinkovich Entry into Tertiary N -Acyliminium Ion Chemistry

✍ Scribed by Ollero, Lourdes; Mentink, Gertjan; Rutjes, Floris P. J. T.; Speckamp, W. Nico; Hiemstra, Henk

Book ID
120662445
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
139 KB
Volume
1
Category
Article
ISSN
1523-7060

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πŸ“œ SIMILAR VOLUMES

A concise synthesis of AG5473/5507 utili
A concise synthesis of AG5473/5507 utilizing N-acyliminium ion chemistry
✍ Chuangxing Guo; Siegfried Reich; Rich Showalter; Ernie Villafranca; Liming Dong πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 180 KB

FKBP-12 inhibitors AG5473 and AG5507 were resynthesized through a more ecient 11-step sequence. The key steps involved propargyl trimethylsilane addition to an N-acyliminium ion, ozonolysis of the allene and acid-catalyzed cyclization. A mild protocol for introducing a formaldehyde moiety to an ano