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A knowledge-based system for automatic interpretation of an analytical profile of complement factors

✍ Scribed by Fred Wiener; Torgny Groth; Ulf Nilsson

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 761 KB
Volume: 3
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.1860030506

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✦ Synopsis

A comprehensive assay to evaluate the complement system includes functional tests of both classical and alternative pathways and immunochemical measurements of C3, C4, B, C1-INA, and C3d. The purpose of this analytical profile is to screen for rare hereditary deficiencies and acquired abnormalities of complement and to define the activation pathway in cases of complement consumptive processes. Based on several years' experience, a routine was established in our laboratory to report the data to the clinician, together with acomputer-generated interpretive statement. This routine was formulated into a

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