✦ LIBER ✦

A kinetic study of vesicle fusion on silicon dioxide surfaces by ellipsometry

✍ Scribed by Dimitrios Stroumpoulis; Alejandro Parra; Matthew Tirrell

Publisher: American Institute of Chemical Engineers
Year: 2006
Tongue: English
Weight: 206 KB
Volume: 52
Category: Article
ISSN: 0001-1541
DOI: 10.1002/aic.10914

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✦ Synopsis

Abstract

Ellipsometry and a mass transport model were used to investigate the kinetics of lipid bilayer formation on silicon dioxide surfaces from 100 nm diameter 1,2‐dimyristoyl‐sn‐glycero‐3‐phosphocholine (DMPC) vesicles. For the range of concentrations studied, 0.025 to 0.380 mg/mL, the rate of the process was found to be concentration dependent and adsorption limited. Further experiments, particularly at concentrations > 0.380 mg/mL, presented evidence of net mass desorption as an intermediate step to supported lipid bilayer formation. © 2006 American Institute of Chemical Engineers AIChE J, 2006

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