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A Key Role for TRPM7 Channels in Anoxic Neuronal Death

✍ Scribed by Michelle Aarts; Koji Iihara; Wen-Li Wei; Zhi-Gang Xiong; Mark Arundine; Waldy Cerwinski; John F. MacDonald; Michael Tymianski

Book ID
117269743
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
960 KB
Volume
115
Category
Article
ISSN
0092-8674

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## Abstract Global ischemia was induced in gerbil by bilateral occlusion of the common carotid arteries for 5 min. Sodium ionophore monensin or sodium channel blocker tetrodotoxin (TTX) was administered at doses of 10 ΞΌg/kg, i.p., 30 min before ischemia induction; the dose was repeated after 22 hr.