A K-ras 13GLY → ASP mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?
✍ Scribed by Beate Fossum; Jarle Breivik; Gunn Iren Meling; Tobias Gedde-Dahl Iii; Torbjørn Hansen; Ingebjørg Knutsen; Torleiv O. Rognum; Erik Thorsby; Gustav Gaudernack
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 704 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
We have characterized and described in detail 2 CD4' T-lymphocyte clones (TLC) from a colonic cancer patient. These TLC specifically recognize a K-rat-derived peptide carrying the I3Asp mutation commonly found in adenocarcinornas of the colon. The TLC were independently derived, as they carried 2 different T-cell receptors. The TLC recognized partly overlapping epitopes within the I3Asp peptide, presented by HLA-DQ7 molecules, suggesting that this molecule might confer some protective immunity against the mutation. On the basis of analysis of 25 I colonic carcinomas, the presence of HLA-DQ7 did not seem to protect against the establishment of carcinomas carrying the I3Asp mutation, since the frequency of the 0 0 7 haplotype was not decreased among patients having this mutation. A modifying effect of DQ7 on the development of carcinomas with a I3Asp mutation was, however, observed, resulting in fewer turnours reaching advanced Dukes stages when DQ7 was present.