A hypothesis to explain why translation inhibitors stabilize mRNAs in mammalian cells: mRNA Stability and mitosis

INTRACISTERNAL A-PARTICLE (IAP)-MEDIATED

INTRACISTERNAL A-PARTICLE (IAP)-MEDIATED LEUKEMOGENESIS: LEVELS AND STABILITY OF IAP mRNA IN FDC-P1 CELLS EXPOSED TO THE CONDITIONS OF AN IRRADIATED ENVIRONMENT

✍ MARION BLUMENSTEIN; UWE TESSMER; DIETER KURT HOSSFELD; ULRICH DÜHRSEN 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 334 KB

Following injection into sublethally irradiated DBA/2 or BALB/c mice, factor-dependent FDC-P1 cells undergo leukemic transformation due to oncogene activation by insertion of intracisternal A-particle (IAP) genetic elements. Similar events are observed in vitro during coculture of FDC-P1 cells with