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A Hypothesis Concerning the Mechanism of Gene Action

โœ Scribed by LINDEGREN, CARL C.


Book ID
109614519
Publisher
Nature Publishing Group
Year
1961
Tongue
English
Weight
812 KB
Volume
189
Category
Article
ISSN
0028-0836

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Hypothesis: Thalidomide embryopathy?prop
โœ Stephens, Trent D.; Fillmore, Bradley J. ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 98 KB ๐Ÿ‘ 1 views

We propose that thalidomide affects the following pathway during limb development: Growth factors (FGF-2 and IGF-I) attach to receptors on limb bud mesenchymal cells and initiate some second messenger system (perhaps SP-1), which activates โฃv and โค3 integrin subunit genes. The resulting โฃv โค3 integr