A hyper-heuristic approach to sequencing by hybridization of DNA sequences
β Scribed by Jacek Blazewicz, Edmund K. Burke, Graham Kendall, Wojciech Mruczkiewicz, Ceyda Oguz, Aleksandra Swiercz
- Book ID
- 120966599
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 625 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0254-5330
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In the paper, the question of the complexity of the combinatorial part of the DNA sequencing by hybridization, is analyzed. Subproblems of the general problem, depending on the type of error (positive, negative), are distinguished. Since decision versions of the subproblems assuming only one type of
## Inspired by the Paracelsus Challenge of Rose and Creamer (Proteins 19: 1-3, 1994), we have designed a protein sequence that is 50% identical to an all-helical protein but is intended to fold into a largely β€-sheet structure. Rather than attempt a de novo design, our strategy was to construct a h