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A Hydrophobic Starch Polymer for Nanoparticle-Mediated Delivery of Docetaxel

✍ Scribed by Prajakta Dandekar; Ratnesh Jain; Thomas Stauner; Brigitta Loretz; Marcus Koch; Gerhard Wenz; Claus-Michael Lehr

Book ID: 102934953
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 632 KB
Volume: 12
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201100244

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✦ Synopsis

Abstract

A hydrophobic starch derivative is used for safe and enhanced delivery of anticancer agents. The synthesis and characterization of propyl starch with a controlled degree of substitution to modulate the release of the encapsulated hydrophobic drug is reported. The application of this polymer for formulating nanoparticles of docetaxel, an anti‐cancer agent effective against numerous types of cancers but possessing intrinsic formulation difficulties is described. The solvent emulsification/diffusion technique is used and the synthesis is optimized with respect to several formulation parameters. Uptake studies with these nanoparticles indicate their enhanced internalization by the cancerous cells and their peri‐nuclear localization.magnified image

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