A hydrophilic plasma polymerized film composite with potential application as an interface for biomaterials
✍ Scribed by Marchant, Roger E. ;Johnson, Steven D. ;Schneider, Bernard H. ;Agger, Mary Patricia ;Anderson, James M.
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 929 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
A hydrophilic polymer composite film (approx. 420 nm thick), with potential application as an interface for biomaterials has been prepared on nonorganic substrates, which include glass, silicon, and aluminum foil, using a glow discharge plasma polymerization technique. A thin film (110 nm thick) polymerized from hexane provided an adherent protective coating for the substrate material, and covalent bonding sites for the outer layer polymerized from N-vinyl-2-pyrrolidone. This outer layer provided the hydrophilic surface or interface. The two layers were copolymerized for a short period during transition between monomers to provide an intimate covalently bonded diffuse interphase. Preliminary in vitro and in uiuo biocompatibility studies indicate that the hydrophilic film is non-cytotoxic, and does not increase the inflammatory response when compared with negative controls.