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A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in α-Helical Conformation

✍ Scribed by Patgiri, Anupam; Jochim, Andrea L.; Arora, Paramjit S.

Book ID
119941372
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
774 KB
Volume
41
Category
Article
ISSN
0001-4842

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Recently, Presta and Rose proposed that a necessary condition for helix formation is the presence of residues at the N- and C-termini (called NTBs and CTBs) whose side chains can form hydrogen bonds with the initial four amides and the last four carbonyls of the helix, which otherwise lack intraheli