## Abstract The application and comparison of selected proteinβ and ligandβbased approaches to elucidate factors important for affinity and selectivity towards the carbonic anhydrase isozymes I, II, and IV are described. Carbonic anhydrases are abundant in proβ and eukaryotes. These enzymes catalyz
A hybrid filter/wrapper approach of feature selection using information theory
β Scribed by Marc Sebban; Richard Nock
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 138 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0031-3203
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β¦ Synopsis
We focus on a hybrid approach of feature selection. We begin our analysis with a ΓΏlter model, exploiting the geometrical information contained in the minimum spanning tree (MST) built on the learning set. This model exploits a statistical test of relative certainty gain, used in a forward selection algorithm. In the second part of the paper, we show that the MST can be replaced by the 1 nearest-neighbor graph without challenging the statistical framework. This leads to a feature selection algorithm belonging to a new category of hybrid models (ΓΏlter-wrapper). Experimental results on readily available synthetic and natural domains are presented and discussed.
π SIMILAR VOLUMES
We thank the Leverhulme Trust (UK) for funding this project, and Mr. Jon Lee for his help in preparation of the template-stripped gold. K.S. thanks Calvin College and the Burroughs-Wellcome Fund for sabbatical support.