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A Humanized Monoclonal Antibody Constructed from Intronless Expression Vectors Targets Human Hepatocellular Carcinoma Cells

โœ Scribed by Kin-Tak Chan; Samuel Chak-Sum Cheng; Hong Xie; Yong Xie


Book ID
115587911
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
212 KB
Volume
284
Category
Article
ISSN
0006-291X

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Monoclonal antibodies with selectivity for human hepatoma cell lines were produced by immunizing BALB/c mice with human hepatoma cell lines, HA22T/VGH or Hep 3B, and fusing sensitized mouse spleen cells with mouse myeloma cells. Two monoclonal antibodies recognizing antigens present only on human he