A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases

Ligation of the T cell antigen receptor

Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk

✍ Hiroko Kanda; Toshihide Mimura; Noritsugu Morino; Ken Hamasaki; Tetsuya Nakamoto 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 728 KB

p105CasL (CasL) is a recently identified signaling molecule closely related to the p130Cas (Crk-associated substrate) docking protein. CasL has a single Src homology (SH) 3 domain in its N-terminal portion followed by multiple consensus motifs for binding to SH2 domains. Like original p130Cas, CasL

A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases

✦ Synopsis