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A homopolymer of the potent antitumor drug 2′-deoxy-5-fluorouridylate

✍ Scribed by Venkataraman Amarnath; Traci L. Miller; Arthur D. Broom

Book ID
119119140
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
419 KB
Volume
741
Category
Article
ISSN
0167-4781

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## Abstract The new amphiphilic dinucleoside phosphate, 2′‐deoxy‐5‐fluorouridylyl‐(3′→5′)‐2′‐deoxy‐5‐fluoro‐__N__^4^‐octadecylcytidine (4) was synthesized on a gram scale, using the phosphotriester method, starting from the cytostatic drug 2′‐deoxy‐5‐fluorouridine (5FdU) and 2′‐deoxy‐5‐fluoro‐__N__