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A Hodgkin-Huxley model exhibiting bursting oscillations

โœ Scribed by Paul R. Shorten; David J.N. Wall

Publisher
Springer
Year
2000
Tongue
English
Weight
285 KB
Volume
62
Category
Article
ISSN
1522-9602

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โœฆ Synopsis

We investigate bursting behaviour generated in an electrophysiological model of pituitary corticotrophs. The active and silent phases of this mode of bursting are generated by moving between two stable oscillatory solutions. The bursting is indirectly driven by slow modulation of the endoplasmic reticulum Ca 2+ concentration. The model exhibits different modes of bursting, and we investigate mode transitions and similar modes of bursting in other Hodgkin-Huxley models. Bifurcation analysis and the use of null-surfaces facilitate a geometric interpretation of the model bursting modes and action potential generation, respectively.

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