A Historical Perspective on Evidence-Based Immunology

✍ Scribed by Moticka, Edward J

• Publisher: Elsevier
• Year: 2015
• Tongue: English
• Leaves: 367
• Edition: 1
• Category: Library

✦ Synopsis

A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights.

The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.

• Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles
• Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology
• Presents concepts such as the division of lymphocytes into functionally different populations in their historical context
• Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells

✦ Table of Contents

Content:
Dedication,Front Matter,Copyright,Foreword,Glossary of Historical TermsEntitled to full textChapter 1 - Innate Host Defense Mechanisms and Adaptive Immune Responses, Pages 1-8
Chapter 2 - Hallmarks of the Adaptive Immune Responses, Pages 9-19
Chapter 3 - Two Effector Mechanisms of the Adaptive Immune Response, Pages 21-29
Chapter 4 - The Small Lymphocyte Is the Antigen Reactive Cell, Pages 31-38
Chapter 5 - Lymphocytes Transform into Plasma Cells and Produce Antibodies, Pages 39-45
Chapter 6 - The Clonal Selection Theory of Antibody Formation, Pages 47-54
Chapter 7 - Plasma Cells Produce Antibody of a Single Specificity, Pages 55-60
Chapter 8 - Self–Non-self Discrimination: How the Immune System Avoids Self-Destruction, Pages 61-67
Chapter 9 - The Thymus in Lymphocyte Maturation, Pages 69-74
Chapter 10 - The Bursa of Fabricius in Lymphocyte Maturation, Pages 75-82
Chapter 11 - Revealing the Structure of the Immunoglobulin Molecule, Pages 83-93
Chapter 12 - Complement, Pages 95-103
Chapter 13 - Antibody Production Requires Thymus-Derived and Bone Marrow (Bursa)-Derived Lymphocyte Interactions, Pages 105-111
Chapter 14 - Cell Collaboration in the Antibody Response: Role of Adherent Cells, Pages 113-120
Chapter 15 - Recognition Structures on Cells of the Innate Host Defense Mechanisms, Pages 121-128
Chapter 16 - The Adaptive Immune Response and Histocompatibility Genes, Pages 129-139
Chapter 17 - Interaction of Lymphocytes with Antigen: Identification of Antigen-Specific Receptors, Pages 141-150
Chapter 18 - Generation of Diversity in the Adaptive Immune Response, Pages 151-158
Chapter 19 - B Lymphocyte Activation, Pages 159-168
Chapter 20 - Activation of T Lymphocytes and MHC Restriction, Pages 169-179
Chapter 21 - Development of Tolerance to Self in B Lymphocytes, Pages 181-188
Chapter 22 - Development of Tolerance to Self in T Lymphocytes, Pages 189-196
Chapter 23 - T Lymphocyte Subpopulations, Pages 197-205
Chapter 24 - T Lymphocyte Control of the Immune Response: From TS to TREG, Pages 207-215
Chapter 25 - Intercellular Communication in the Immune System, Pages 217-226
Chapter 26 - Antibody-Mediated Effector Mechanisms, Pages 227-234
Chapter 27 - T-Lymphocyte-Mediated Effector Mechanisms, Pages 235-242
Chapter 28 - Lymphocytes that Kill: Natural Killer (NK) and Natural Killer T (NKT) Lymphocytes, Pages 243-251
Chapter 29 - Role of Dendritic Cells in the Adaptive Immune Response, Pages 253-259
Chapter 30 - The Mucosal Immune System and Secretory IgA, Pages 261-267
Chapter 31 - Disorders of the Innate Host Defenses, Pages 269-275
Chapter 32 - Defects in the Adaptive Immune Response Leading to Recurrent Infections, Pages 277-285
Chapter 33 - Pathologies Resulting from Aberrant Immune Responses, Pages 287-297
Chapter 34 - Immune Responses Directed Against Self, Pages 299-308
Chapter 35 - Lymphoproliferative Diseases, Pages 309-316
Chapter 36 - Transplantation Immunology, Pages 317-327
Chapter 37 - Tumor Immunology, Pages 329-339
Chapter 38 - Therapies That Manipulate Host Defense Mechanisms, Pages 341-352
Chapter 39 - Techniques to Detect and Quantify Host Defenses, Pages 353-364
Chapter 40 - The Future of Immunology, Pages 365-371
Index, Pages 373-380