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A Hinge Region cis-Proline in Ribonuclease A Acts as a Conformational Gatekeeper for C-Terminal Domain Swapping

✍ Scribed by Katherine H. Miller; Jessica R. Karr; Susan Marqusee


Book ID
116664429
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
939 KB
Volume
400
Category
Article
ISSN
0022-2836

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Propensity for C-terminal domain swappin
✍ Katherine H. Miller; Susan Marqusee πŸ“‚ Article πŸ“… 2011 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 347 KB

## Abstract Domain swapping is a type of oligomerization in which monomeric proteins exchange a structural element, resulting in oligomers whose subunits recapitulate the native, monomeric fold. It has been implicated as a potential mechanism for protein aggregation, which provides a strong impetus