Conformational changes of the p53-bindin
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L. M. Espinoza-Fonseca; José G. Trujillo-Ferrara
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Article
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2006
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Wiley (John Wiley & Sons)
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English
⚖ 310 KB
## Abstract Two 35‐ns molecular dynamics simulations of both ligated [mouse double minute protein 2 (MDM2^p53^)] and unligated (MDM2^apo^) structures of human MDM2 bound to the N‐terminal domain of the tumor suppressor p53 have been performed. Analysis of the dynamics revealed that the most flexibl