𝔖 Bobbio Scriptorium
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A highly stereoselective condensation process for the conversion of carbonyl compounds to α,β-unsaturated thiol esters.

✍ Scribed by Donald H. Lucast; James Wemple


Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
278 KB
Volume
18
Category
Article
ISSN
0040-4039

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✦ Synopsis


Coenzyme A thiol ester derivatives serve as important intermediates in biochemical condensation and acyl transfer reactions. Despite the biosynthetic importance of the thiol ester function, relatively little attention has been


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## ABSTRACT A sensitive fluorogenic probe **1** for biothiols was developed based on the Michael addition reaction. The probe **1** was readily synthesized via the reaction of 2‐(4′‐hydroxyphenyl) benzimidazole (HPBI) with acryloyl chloride and shows weak fluorescence emission. Upon mixing with bio