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A highly sensitive periodic acid-silver stain for 1,2-diol groups of glycoproteins and polysaccharides in polyacrylamide gels

✍ Scribed by Gérard Dubray; Guy Bezard


Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
347 KB
Volume
119
Category
Article
ISSN
0003-2697

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✦ Synopsis


A highly sensitive silver stain for visualizing proteins in polyacrylamide gels was adapted for staining 1,2-diol groups of carbohydrates. This periodic acid-silver stain is 64 times more sensitive than the periodic acid-Schiff stain, and the lower limit of detection is about 0.4 ng of bound carbohydrates. Its lower limit of detection is comparable to autoradiography of radioactively labeled lipopolysaccharides.