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A highly practical synthesis of the sialyl Lewis X pentasaccharide and an investigation of binding to E-, P-, and L-Selectins

✍ Scribed by Takao Kiyoi; Yoshiyuki Nakai; Hirosato Kondo; Hideharu Ishida; Makoto Kiso; Akira Hasegawa

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 884 KB
Volume: 4
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(96)00105-8

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## Abstract Grb7 is a member of the Grb7 family of proteins, which also includes Grb10 and Grb14. All three proteins have been found to be overexpressed in certain cancers and cancer cell lines. In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20–30% of breast