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A Highly Efficient Strategy for Modification of Proteins at the C Terminus

✍ Scribed by Long Yi; Dr. Hongyan Sun; Dr. Yao-Wen Wu; Dr. Gemma Triola; Prof. Herbert Waldmann; Prof. Roger S. Goody

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
569 KB
Volume
49
Category
Article
ISSN
0044-8249

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✍ Igor A. Kozlov; Peter C. Melnyk; Katie E. Stromsborg; Mark S. Chee; David L. Bar πŸ“‚ Article πŸ“… 2004 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 146 KB πŸ‘ 1 views

## Abstract Three methods for the conjugation of oligonucleotides to antibodies and the subsequent application of these conjugates to protein detection at attomole levels in immunoassays are described. The methods are based on chemical modification of both antibody and oligonucleotide. Aldehydes we