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A highly efficient route to dehydroalanine containing peptides

✍ Scribed by Sarah A. Burrage; Tony Raynham; Mark Bradley

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
227 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A routine method for the synthesis of dehydroalanine containing peptides has been developed. These residues are introduced as S-methyl cysteines which are subsequently oxidised and eliminated. The approach is compatible with both Boc and Fmoc protection strategies and can allow the introduction of a number of ot13 unsaturated amino acids into peptides during synthesis.

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