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A Highly Efficient and Enantioselective Access to Tetrahydroisoquinoline Alkaloids: Asymmetric Hydrogenation with an Iridium Catalyst

✍ Scribed by Mingxin Chang; Wei Li; Prof. Xumu Zhang


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
319 KB
Volume
123
Category
Article
ISSN
0044-8249

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## Abstract A modular synthesis for chiral and non‐symmetrical salalen ligands (i.e., mono‐reduced salens), carrying an imine and an amine functionality has been developed. The ligands can be assembled __in situ__ by Schiff base formation of an __N__‐(2‐hydroxybenzyl)diamine with a salicylic aldehy