A highly diastereoselective synthesis of isoindolinone-centered Meyers’ tetracyclic lactams. Application to the asymmetric synthesis of 3-alkylisoindolinones
✍ Scribed by Vangelis Agouridas; Frédéric Capet; Axel Couture; Eric Deniau; Pierre Grandclaudon
- Book ID
- 113929526
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 612 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
Condensation of 2-formylbenzoic acid with a-amino alcohol substrates proceeds with extremely high diaslereoselectivity to produce tricyclic T-lactam pn~lucts. The relative slereochemislxy of the major diasmreoisomer has been determined by X-ray crystal analysis and a mechanism suggested to explain t
2, which may be rationalized in a straightforward the situation here is more complex. With non-symmetric phosphinoaryldihydrooxazoles, two diastereomeric ally1 palladium intermediates must be considered, and in addition to steric interactions, electronic effects may play a role as well (differing tr