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A Highly Convergent Synthesis of 2‐Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors

✍ Scribed by Yan, Hongxing; Kerns, Jeffrey K.; Jin, Qi; Zhu, Chongjie; Barnette, Mary S.; Callahan, James F.; Hay, Douglas W. P.; Jolivette, Larry J.; Luttmann, Mark A.; Sarau, Henry M.


Book ID
115481209
Publisher
Taylor and Francis Group
Year
2005
Tongue
English
Weight
105 KB
Volume
35
Category
Article
ISSN
0039-7911

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Synthesis of New 4-Heteroaryl-2-Phenylqu
✍ Anna Borioni; Carlo Mustazza; Isabella Sestili; Maria Sbraccia; Luciana Turchett 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 923 KB

## Abstract Substituted 4‐heteroaryl‐2‐phenylquinolines were synthesized and tested on NK‐2 and NK‐3 receptors in order to get a better insight in the structure‐activity relationship. On the whole, these molecules, which can be regarded as bioisosters of the NK‐3 antagonist SB 218795, displayed a l