A highly convergent approach for the synthesis of disaccharide repeating units of peptidoglycan
β Scribed by Abhijit Roy Chowdhury; Aloysius Siriwardena; Geert-Jan Boons
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 183 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A highly convergent strategy has been developed for the synthesis of the two possible saccharide-repeating units of peptidoglycan using TBDMS and PMB ethers as orthogonal protecting groups and a two-directional glycosylation strategy for the efficient assembly of the spacer containing disaccharides.
π SIMILAR VOLUMES
Glycosylation of the readily accessible benzyl 2-acetamido-6-O-benzyl-2-deoxy-3-O-[(R)-1-(methoxycarbonyl)ethyl]-alpha- D- glucopyranoside with 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-beta-D-glucopyranosyl chloride (2), using the silver triflate method in the absence of a base, afforded 65-70% of t