A highly convergent and flexible strategy for the synthesis of a-ring aromatic steroids

✍ Scribed by Lewis N. Mander; John V. Turner

• Publisher: Elsevier Science
• Year: 1981
• Tongue: French
• Weight: 244 KB
• Volume: 22
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)81993-6

✦ Synopsis

Using Hendrickson's criteria for systematic synthesis design, a strategy featuring a linear six carbon synthon (7) for bis-annulation has been devised for economic, flexible and highly convergent syntheses of A-ring aromatic steroids.

New A-ring aromatic steroids continue to be prime synthetic targets' for potential use in fertility control, bioassays, or as antineoplastic agents. ' By using