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A highly conserved sequence on the short arm of chromosome 7 detects multiple polymorphisms

✍ Scribed by B. Bardoni; S. Guioli; E. Maserati; P. Maraschio; G. Camerino

Publisher: Springer
Year: 1988
Tongue: English
Weight: 602 KB
Volume: 81
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00283723

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✦ Synopsis

We have isolated a human DNA fragment (laboratory acronym G98) that detects related sequences in mammals, chicken and Drosophila DNAs. This sequence has been mapped to human chromosome 7 p14-p15 by in situ hybridization. Probe G98 recognizes an insertion-deletion type polymorphism, with allelic frequencies of about 0.5, which can be detected with at least six different restriction enzymes. A second polymorphism, which can be detected in human DNA digested with TaqI, is in non-complete linkage disequilibrium with the first polymorphism. About 70% of the individuals analysed have been found to be heterozygous at this locus.

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