A highly active palladium catalyst system for the arylation of anilines

✍ Scribed by Joseph P. Sadighi; Michele C. Harris; Stephen L. Buchwald

• Book ID: 104259489
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 234 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00988-5

✦ Synopsis

The chelating ligand bis [2-(diphenylphosphino)phenyl] ether (DPEphos), in combination with palladium acetate, forms a highly active catalyst system for the coupling of anilines with aryl bromides. The bisphosphine is easily prepared in large quantity and at low cost by a known procedure. The catalyst system is effective in coupling reactions involving a variety of substrates, including electron-poor anilines or electron-rich aryl bromides. In addition, it tolerates a high degree of sterie congestion at both the aniline and the aryl bromide.