Fluorous Base-Pairing Effects in a DNA P
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Jacob S. Lai; Eric T. Kool
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Article
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2005
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John Wiley and Sons
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English
⚖ 258 KB
## Abstract We describe selective “fluorous” effects in the active site of a DNA polymerase, by using nucleotide analogues whose pairing edges are perfluorinated. The 5′‐triphosphate deoxynucleotide derivatives of DNA base analogues 2,3,4,5‐tetrafluorobenzene (^**F**^**B**) and 4,5,6,7‐tetrafluoroi